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KMID : 1161420180210121197
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Journal of Medicinal Food
2018 Volume.21 No. 12 p.1197 ~ p.1203
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Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study
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Karkabounas Spyridon
Papadopoulos Nikolaos
Anastasiadou Chryssa
Gubili Chrysoula
Peschos Dimitrios
Daskalou Telemachos
Fikioris Nikolaos
Simos Yannis V.
Kontargiris Evangelos
Gianakopoulos Xenophon
Ragos Vasilios
Chatzidimitriou Maria
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Abstract
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Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients. We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementation with α-lipoic acid (ALA), carnosine, and thiamine. For that purpose, 82 obese type 2 diabetic patients were randomly assigned to 2 groups, and were either supplemented daily with 7?mg ALA/kg body weight, 6?mg carnosine/kg body weight, and 1?mg thiamine/kg body weight or placebo for 8 weeks. An array of biochemical tests including the estimation of oxidative stress and platelet aggregation were performed at baseline and at follow-up. Moreover, the antiplatelet activity of each of the supplement's components was determined ex vivo at human and washed rabbit platelets. Glucose and HbA1c levels were significantly reduced after supplementation (135.7?±?19.5?mg/dL vs. 126.5?±?16.8?mg/dL and 8.3%?±?0.3% vs. 6.03%?±?0.58%, respectively, P?
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KEYWORD
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glucose, glycated hemoglobin A, insulin, obesity, oxidative stress, platelet aggregation
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